Humanin

Description

Buy Humanin (HN) — Research-Grade Mitochondrial-Derived Peptide

Buy humanin (HN) — a 24-amino-acid mitochondrial-derived peptide (MDP) encoded within the MT-RNR2 (16S rRNA) region of the mitochondrial genome, supplied lyophilized at ≥99% purity for laboratory research.

What Is Humanin?

Humanin was the first mitochondrial-derived peptide identified, discovered while screening cDNA from the brain tissue of a familial Alzheimer’s patient. Mechanism: it inhibits apoptosis through two distinct arms — extracellular signalling via FPR2/3 and the CNTFR/WSX-1/gp130 receptor complex, and direct intracellular binding of pro-apoptotic Bax. It also binds IGFBP-3, modulating IGF-1 signalling, and crosses the blood–brain barrier in rodent models.

Humanin Research Findings

Plasma humanin levels decline with age, while centenarians and their offspring show elevated levels. Preclinical models have reported neuroprotection against amyloid-β toxicity in Alzheimer’s models, cardioprotection in myocardial infarction models, protection of retinal pigment epithelial cells from oxidative stress, and improved glucose homeostasis and insulin sensitivity — establishing the humanin peptide as a cornerstone of mitochondrial peptide research.

HNG (S14G-Humanin)

HNG is the most widely studied humanin analog, carrying a single amino-acid substitution at position 14 that increases activity to nanomolar concentrations in published assays. Much of the cell and animal literature — including anti-inflammatory findings in NF-κB and NLRP3 pathways — uses HNG rather than native humanin, making the native peptide the reference compound for analog comparison studies.

Humanin for Sale — Purity & Testing

VMAX humanin is supplied as a lyophilized research compound verified to ≥99% purity by HPLC and mass spectrometry. Humanin is often studied alongside MOTS-c, the other major mitochondrial-derived peptide, in comparative MDP research.

Storage & Reconstitution

Handling: Lyophilized peptide. Store sealed at -20°C for long-term stability or 2–8°C short-term. Reconstitute with bacteriostatic water or 0.6% acetic acid as appropriate to the molecule. After reconstitution, store at 2–8°C and avoid repeated freeze-thaw cycles.

For research purposes only. Not for human consumption. This material is intended exclusively for in-vitro laboratory and preclinical research applications conducted by qualified personnel.