MOTS-c

Description

MOTS-c for Sale — Research-Grade Mitochondrial-Derived Peptide

MOTS-c for sale for laboratory research — MOTS-c (Mitochondrial ORF of the Twelve S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the 12S rRNA (MT-RNR1) region of the mitochondrial genome, supplied lyophilized at ≥99% purity.

What Is MOTS-c?

MOTS-c was identified in 2015 as the first mitochondrial-derived peptide encoded in the 12S rRNA gene. Mechanism: under metabolic stress, MOTS-c translocates to the cell nucleus and regulates nuclear gene expression — a rare example of mitochondria-to-nucleus retrograde signalling by a peptide. Its metabolic activity runs through inhibition of the folate cycle and de novo purine synthesis, driving AICAR accumulation and AMPK activation, the same master pathway engaged by exercise and caloric restriction.

MOTS-c Research Findings

In preclinical models, MOTS-c administration prevented diet-induced obesity and insulin resistance in mice on a high-fat diet and reversed age-dependent insulin resistance in skeletal muscle. Circulating MOTS-c rises with exercise in humans, and treatment improved physical performance in aged mice — the basis of its “exercise-mimetic” framing in the literature. A naturally occurring variant (K14Q, from the m.1382A>C polymorphism) has been studied in East Asian longevity cohorts, linking MOTS-c biology to human aging research.

MOTS-c vs Humanin

MOTS-c and humanin are the two most studied mitochondrial-derived peptides, encoded in different rRNA regions of the mitochondrial genome — MOTS-c in the 12S, humanin in the 16S. Research emphasis differs: MOTS-c dominates metabolic and exercise-physiology studies, while humanin is the reference compound in cytoprotection and apoptosis research, making the pair standard comparators in MDP studies.

Is VMAX MOTS-c third-party tested?

Yes our MOTS-c is third party tested in the USA

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Lab Verified > 99% purity · View lab results →

Storage & Reconstitution

Handling: Lyophilized peptide. Store sealed at -20°C for long-term stability or 2-8°C short-term. Reconstitute with bacteriostatic water. After reconstitution, store at 2–8°C and avoid repeated freeze-thaw cycles.
For research purposes only. Not for human consumption. This material is intended exclusively for in-vitro laboratory and preclinical research applications conducted by qualified personnel.

What is MOTS-c?

MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA gene, studied for AMPK-mediated metabolic regulation and exercise-mimetic activity in preclinical research.

What is the purity of this MOTS-c?

MOTS-c is supplied as a lyophilized research compound verified to ≥99% purity by HPLC and mass spectrometry.

How should MOTS-c be stored?

Store the lyophilized peptide sealed at -20°C for long-term stability, or 2–8°C short-term. After reconstitution, store at 2–8°C and avoid repeated freeze-thaw cycles.

What is the difference between MOTS-c and humanin?

Both are mitochondrial-derived peptides, but MOTS-c is encoded in the 12S rRNA gene and studied mainly for metabolic and exercise-related signalling, while humanin is encoded in the 16S rRNA gene and studied mainly for cytoprotective and anti-apoptotic activity.

Is this MOTS-c for human use?

No. This material is sold strictly for in-vitro laboratory and preclinical research by qualified personnel. It is not for human or veterinary use.

What vial sizes are available?

MOTS-c is available in multiple vial sizes — select your preferred option on this product page.